Can Qwen2.5 3B Instruct run on AMD Instinct MI325X 256GB?

YES — Runs Great

C42Usable

Estimated from fit model

Qwen2.5 3B Instruct needs ~28.7 GB VRAM. AMD Instinct MI325X 256GB has 256.0 GB. With Q4_K_M quantization, expect ~42 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 28.7 GB, 42.0 tok/s, Runs well

28.7 GB required256.0 GB available

11% VRAM used

Fit status

Runs well

Decode

42.0 tok/s

TTFT

4610 ms

Safe context

10.4M

Memory

28.7 GB / 256.0 GB

Memory breakdown

Weights1.8 GB

KV Cache0.4 GB

Runtime0.9 GB

Headroom25.6 GB

See how fast it feels

See how fast it feelsQwen2.5 3B Instruct on AMD Instinct MI325X 256GB
1st promptCold start — includes initialization
>What is local AI inference?
Local AI inference means running an AI language model directly on your own hardware — your laptop, desktop, or server — instead of sending requests to a remote cloud API.

When you run inference locally the model weights are loaded into your GPU or unified memory. Each token you generate requires reading those weights from memory, so memory bandwidth is the main bottleneck for decode speed.

Key benefits of running locally:
  - Full privacy: your prompts never leave your machine
  - No per-token cost or rate limits
  - Works offline once the model is downloaded
  - Latency depends only on your hardware
2nd promptWarm — model ready, no init overhead
>How much VRAM do I need?
It depends on the model size and quantization level. A rough rule of thumb:

  Model size     Q4 (4-bit)    Q8 (8-bit)    FP16
  7B params      ~4.3 GB       ~7.5 GB       ~14 GB
  13B params     ~7.9 GB       ~13.9 GB      ~26 GB
  70B params     ~42.7 GB      ~74.9 GB      ~140 GB

Most people use 4-bit quantization (Q4_K_M) which gives 90-95% of full quality at a fraction of the memory. A 24 GB GPU can comfortably run most 7B-13B models.
Estimated: 42.0 tok/s decode · 4.6s TTFT (warm) · 105 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	C	Runs well	42.0 tok/s	2514 ms	10.4M
Coding	C	Runs well	42.0 tok/s	4610 ms	10.4M
Agentic Coding	C	Runs well	42.0 tok/s	6705 ms	10.4M
Reasoning	C	Runs well	42.0 tok/s	5448 ms	10.4M
RAG	C	Runs well	42.0 tok/s	8381 ms	10.4M

Quantization options

How Qwen2.5 3B Instruct (3B params) fits at each quantization level on AMD Instinct MI325X 256GB (256.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	1.2 GB	Low	D36
Q3_K_S	3	1.5 GB	Low	D36
NVFP4	4

Get started

Copy-paste commands to run Qwen2.5 3B Instruct on your machine.

Run

lms load hf-qwen--qwen2-5-3b-instruct-gguf && lms server start

Frequently asked questions

Can AMD Instinct MI325X 256GB run Qwen2.5 3B Instruct?

Yes, AMD Instinct MI325X 256GB can run Qwen2.5 3B Instruct with a C grade (Runs well). Expected decode speed: 42.0 tok/s.

How much VRAM does Qwen2.5 3B Instruct need?

Qwen2.5 3B Instruct (3B parameters) requires approximately 28.7 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen2.5 3B Instruct?

The recommended quantization for Qwen2.5 3B Instruct is Q4_K_M, which balances quality and memory efficiency.

What speed will Qwen2.5 3B Instruct run at on AMD Instinct MI325X 256GB?

On AMD Instinct MI325X 256GB, Qwen2.5 3B Instruct achieves approximately 42.0 tokens per second decode speed with a time-to-first-token of 4610ms using Q4_K_M quantization.

Can AMD Instinct MI325X 256GB run Qwen2.5 3B Instruct for coding?

For coding workloads, Qwen2.5 3B Instruct on AMD Instinct MI325X 256GB receives a C grade with 42.0 tok/s and 10.4M context.

What context window can Qwen2.5 3B Instruct use on AMD Instinct MI325X 256GB?

On AMD Instinct MI325X 256GB, Qwen2.5 3B Instruct can safely use up to 10.4M tokens of context. The model's official context limit is —, but available memory constrains the safe maximum.

See all results for AMD Instinct MI325X 256GB See all hardware for Qwen2.5 3B Instruct

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