Can Nous Hermes 2 Mistral 7B DPO run on AMD Instinct MI250 128GB?

YES — Runs Great

C45Usable

Estimated from fit model

Nous Hermes 2 Mistral 7B DPO needs ~18.8 GB VRAM. AMD Instinct MI250 128GB has 128.0 GB. With Q4_K_M quantization, expect ~98 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 18.8 GB, 98.0 tok/s, Runs well

18.8 GB required128.0 GB available

15% VRAM used

Fit status

Runs well

Decode

98.0 tok/s

TTFT

1976 ms

Safe context

2.1M

Memory

18.8 GB / 128.0 GB

Memory breakdown

Weights4.3 GB

KV Cache0.8 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsNous Hermes 2 Mistral 7B DPO on AMD Instinct MI250 128GB
1st promptCold start — includes initialization
>What is local AI inference?
Local AI inference means running an AI language model directly on your own hardware — your laptop, desktop, or server — instead of sending requests to a remote cloud API.

When you run inference locally the model weights are loaded into your GPU or unified memory. Each token you generate requires reading those weights from memory, so memory bandwidth is the main bottleneck for decode speed.

Key benefits of running locally:
  - Full privacy: your prompts never leave your machine
  - No per-token cost or rate limits
  - Works offline once the model is downloaded
  - Latency depends only on your hardware
2nd promptWarm — model ready, no init overhead
>How much VRAM do I need?
It depends on the model size and quantization level. A rough rule of thumb:

  Model size     Q4 (4-bit)    Q8 (8-bit)    FP16
  7B params      ~4.3 GB       ~7.5 GB       ~14 GB
  13B params     ~7.9 GB       ~13.9 GB      ~26 GB
  70B params     ~42.7 GB      ~74.9 GB      ~140 GB

Most people use 4-bit quantization (Q4_K_M) which gives 90-95% of full quality at a fraction of the memory. A 24 GB GPU can comfortably run most 7B-13B models.
Estimated: 98.0 tok/s decode · 2.0s TTFT (warm) · 245 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	C	Runs well	98.0 tok/s	1078 ms	2.1M
Coding	C	Runs well	98.0 tok/s	1976 ms	2.1M
Agentic Coding	C	Runs well	98.0 tok/s	2873 ms	2.1M
Reasoning	C	Runs well	98.0 tok/s	2335 ms	2.1M
RAG	C	Runs well	98.0 tok/s	3592 ms	2.1M

Quantization options

How Nous Hermes 2 Mistral 7B DPO (7B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	2.7 GB	Low	D38
Q3_K_S	3	3.4 GB	Low	D38
NVFP4	4

Get started

Copy-paste commands to run Nous Hermes 2 Mistral 7B DPO on your machine.

Run

lms load hf-nousresearch--nous-hermes-2-mistral-7b-dpo-gguf && lms server start

Upgrade options

Hardware that runs Nous Hermes 2 Mistral 7B DPO well

Mac Studio M3 Ultra 256GBBudget pick

256 GB Unified (+128)

Adds memory headroom for longer context windows and future model growth.98 tok/s decode

Adds memory headroom for longer context windows and future model growth.

~$6,999 MSRP

Frequently asked questions

Can AMD Instinct MI250 128GB run Nous Hermes 2 Mistral 7B DPO?

Yes, AMD Instinct MI250 128GB can run Nous Hermes 2 Mistral 7B DPO with a C grade (Runs well). Expected decode speed: 98.0 tok/s.

How much VRAM does Nous Hermes 2 Mistral 7B DPO need?

Nous Hermes 2 Mistral 7B DPO (7B parameters) requires approximately 18.8 GB of memory with Q4_K_M quantization.

What is the best quantization for Nous Hermes 2 Mistral 7B DPO?

The recommended quantization for Nous Hermes 2 Mistral 7B DPO is Q4_K_M, which balances quality and memory efficiency.

What speed will Nous Hermes 2 Mistral 7B DPO run at on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Nous Hermes 2 Mistral 7B DPO achieves approximately 98.0 tokens per second decode speed with a time-to-first-token of 1976ms using Q4_K_M quantization.

Can AMD Instinct MI250 128GB run Nous Hermes 2 Mistral 7B DPO for coding?

For coding workloads, Nous Hermes 2 Mistral 7B DPO on AMD Instinct MI250 128GB receives a C grade with 98.0 tok/s and 2.1M context.

What context window can Nous Hermes 2 Mistral 7B DPO use on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Nous Hermes 2 Mistral 7B DPO can safely use up to 2.1M tokens of context. The model's official context limit is —, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250 128GB See all hardware for Nous Hermes 2 Mistral 7B DPO

Embed this result▼

Paste this snippet into any page to show a live fit card.

<iframe src="https://willitrunai.com/embed/hf-nousresearch--nous-hermes-2-mistral-7b-dpo-gguf-on-instinct-mi250-128gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>

Preview: