Can Hermes 4.3 36B run on AMD Instinct MI210 64GB?

YES — Runs Great

C51Usable

Estimated from fit model

Hermes 4.3 36B needs ~33.5 GB VRAM. AMD Instinct MI210 64GB has 64.0 GB. With Q4_K_M quantization, expect ~51 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 33.5 GB, 50.7 tok/s, Runs well

33.5 GB required64.0 GB available

52% VRAM used

Fit status

Runs well

Decode

50.7 tok/s

TTFT

3817 ms

Safe context

132K

Memory

33.5 GB / 64.0 GB

Memory breakdown

Weights22.0 GB

KV Cache4.2 GB

Runtime0.9 GB

Headroom6.4 GB

See how fast it feels

See how fast it feelsHermes 4.3 36B on AMD Instinct MI210 64GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
  - Speed = 60 mph (miles per hour)
  - Time  = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
  Distance = 60 mph x 2.5 h
           = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
  - First half: 1.25 hours at 60 mph = 75 miles
  - Stop: 20 minutes (no distance)
  - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 50.7 tok/s decode · 3.8s TTFT (warm) · 127 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	C	Runs well	50.7 tok/s	2082 ms	132K
Coding	C	Runs well	50.7 tok/s	3817 ms	132K
Agentic Coding	C	Runs well	50.7 tok/s	5552 ms	132K
Reasoning	C	Runs well	50.7 tok/s	4511 ms	132K
RAG	C	Runs well	50.7 tok/s	6940 ms	132K

Quantization options

How Hermes 4.3 36B (36B params) fits at each quantization level on AMD Instinct MI210 64GB (64.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	14.0 GB	Low	C42
Q3_K_S	3	17.6 GB	Low	C43
NVFP4	4

Get started

Copy-paste commands to run Hermes 4.3 36B on your machine.

Run

lms load hf-nousresearch--hermes-4-3-36b-gguf && lms server start

Upgrade options

Hardware that runs Hermes 4.3 36B well

NVIDIA H800 80GBBudget pick

80 GB VRAM (+16)3000 GB/s (+1362)

Raises estimated decode speed by about 118%.110.7 tok/s decode

Raises estimated decode speed by about 118%.

Adds memory headroom for longer context windows and future model growth.

~$30,000 MSRP

NVIDIA H100 80GBBest value

80 GB VRAM (+16)3350 GB/s (+1712)

Raises estimated decode speed by about 153%.128.1 tok/s decode

Raises estimated decode speed by about 153%.

Adds memory headroom for longer context windows and future model growth.

~$40,000 MSRP

Frequently asked questions

Can AMD Instinct MI210 64GB run Hermes 4.3 36B?

Yes, AMD Instinct MI210 64GB can run Hermes 4.3 36B with a C grade (Runs well). Expected decode speed: 50.7 tok/s.

How much VRAM does Hermes 4.3 36B need?

Hermes 4.3 36B (36B parameters) requires approximately 33.5 GB of memory with Q4_K_M quantization.

What is the best quantization for Hermes 4.3 36B?

The recommended quantization for Hermes 4.3 36B is Q4_K_M, which balances quality and memory efficiency.

What speed will Hermes 4.3 36B run at on AMD Instinct MI210 64GB?

On AMD Instinct MI210 64GB, Hermes 4.3 36B achieves approximately 50.7 tokens per second decode speed with a time-to-first-token of 3817ms using Q4_K_M quantization.

Can AMD Instinct MI210 64GB run Hermes 4.3 36B for coding?

For coding workloads, Hermes 4.3 36B on AMD Instinct MI210 64GB receives a C grade with 50.7 tok/s and 132K context.

What context window can Hermes 4.3 36B use on AMD Instinct MI210 64GB?

On AMD Instinct MI210 64GB, Hermes 4.3 36B can safely use up to 132K tokens of context. The model's official context limit is —, but available memory constrains the safe maximum.

See all results for AMD Instinct MI210 64GB See all hardware for Hermes 4.3 36B

Embed this result▼

Paste this snippet into any page to show a live fit card.

<iframe src="https://willitrunai.com/embed/hf-nousresearch--hermes-4-3-36b-gguf-on-instinct-mi210-64gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>

Preview: