Can Hermes 2 Pro Mistral 7B run on AMD Instinct MI350X 288GB?

YES — Runs Great

C44Usable

Estimated from fit model

Hermes 2 Pro Mistral 7B needs ~34.8 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~98 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 34.8 GB, 98.0 tok/s, Runs well

34.8 GB required288.0 GB available

12% VRAM used

Fit status

Runs well

Decode

98.0 tok/s

TTFT

1976 ms

Safe context

5.0M

Memory

34.8 GB / 288.0 GB

Memory breakdown

Weights4.3 GB

KV Cache0.8 GB

Runtime0.9 GB

Headroom28.8 GB

See how fast it feels

See how fast it feelsHermes 2 Pro Mistral 7B on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>What is local AI inference?
Local AI inference means running an AI language model directly on your own hardware — your laptop, desktop, or server — instead of sending requests to a remote cloud API.

When you run inference locally the model weights are loaded into your GPU or unified memory. Each token you generate requires reading those weights from memory, so memory bandwidth is the main bottleneck for decode speed.

Key benefits of running locally:
  - Full privacy: your prompts never leave your machine
  - No per-token cost or rate limits
  - Works offline once the model is downloaded
  - Latency depends only on your hardware
2nd promptWarm — model ready, no init overhead
>How much VRAM do I need?
It depends on the model size and quantization level. A rough rule of thumb:

  Model size     Q4 (4-bit)    Q8 (8-bit)    FP16
  7B params      ~4.3 GB       ~7.5 GB       ~14 GB
  13B params     ~7.9 GB       ~13.9 GB      ~26 GB
  70B params     ~42.7 GB      ~74.9 GB      ~140 GB

Most people use 4-bit quantization (Q4_K_M) which gives 90-95% of full quality at a fraction of the memory. A 24 GB GPU can comfortably run most 7B-13B models.
Estimated: 98.0 tok/s decode · 2.0s TTFT (warm) · 245 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	C	Runs well	98.0 tok/s	1078 ms	5.0M
Coding	C	Runs well	98.0 tok/s	1976 ms	5.0M
Agentic Coding	C	Runs well	98.0 tok/s	2873 ms	5.0M
Reasoning	C	Runs well	98.0 tok/s	2335 ms	5.0M
RAG	C	Runs well	98.0 tok/s	3592 ms	5.0M

Quantization options

How Hermes 2 Pro Mistral 7B (7B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	2.7 GB	Low	D36
Q3_K_S	3	3.4 GB	Low	D36
NVFP4	4

Get started

Copy-paste commands to run Hermes 2 Pro Mistral 7B on your machine.

Run

lms load hf-nousresearch--hermes-2-pro-mistral-7b-gguf && lms server start

Frequently asked questions

Can AMD Instinct MI350X 288GB run Hermes 2 Pro Mistral 7B?

Yes, AMD Instinct MI350X 288GB can run Hermes 2 Pro Mistral 7B with a C grade (Runs well). Expected decode speed: 98.0 tok/s.

How much VRAM does Hermes 2 Pro Mistral 7B need?

Hermes 2 Pro Mistral 7B (7B parameters) requires approximately 34.8 GB of memory with Q4_K_M quantization.

What is the best quantization for Hermes 2 Pro Mistral 7B?

The recommended quantization for Hermes 2 Pro Mistral 7B is Q4_K_M, which balances quality and memory efficiency.

What speed will Hermes 2 Pro Mistral 7B run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Hermes 2 Pro Mistral 7B achieves approximately 98.0 tokens per second decode speed with a time-to-first-token of 1976ms using Q4_K_M quantization.

Can AMD Instinct MI350X 288GB run Hermes 2 Pro Mistral 7B for coding?

For coding workloads, Hermes 2 Pro Mistral 7B on AMD Instinct MI350X 288GB receives a C grade with 98.0 tok/s and 5.0M context.

What context window can Hermes 2 Pro Mistral 7B use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Hermes 2 Pro Mistral 7B can safely use up to 5.0M tokens of context. The model's official context limit is —, but available memory constrains the safe maximum.

See all results for AMD Instinct MI350X 288GB See all hardware for Hermes 2 Pro Mistral 7B

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