Can HelpingAI2.5 10B i1 run on AMD Instinct MI350X 288GB?

YES — Runs Great

C44Usable

Estimated from fit model

HelpingAI2.5 10B i1 needs ~37.0 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~140 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 37.0 GB, 140.0 tok/s, Runs well

37.0 GB required288.0 GB available

13% VRAM used

Fit status

Runs well

Decode

140.0 tok/s

TTFT

1383 ms

Safe context

3.4M

Memory

37.0 GB / 288.0 GB

Memory breakdown

Weights6.1 GB

KV Cache1.2 GB

Runtime0.9 GB

Headroom28.8 GB

See how fast it feels

See how fast it feelsHelpingAI2.5 10B i1 on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>What is local AI inference?
Local AI inference means running an AI language model directly on your own hardware — your laptop, desktop, or server — instead of sending requests to a remote cloud API.

When you run inference locally the model weights are loaded into your GPU or unified memory. Each token you generate requires reading those weights from memory, so memory bandwidth is the main bottleneck for decode speed.

Key benefits of running locally:
  - Full privacy: your prompts never leave your machine
  - No per-token cost or rate limits
  - Works offline once the model is downloaded
  - Latency depends only on your hardware
2nd promptWarm — model ready, no init overhead
>How much VRAM do I need?
It depends on the model size and quantization level. A rough rule of thumb:

  Model size     Q4 (4-bit)    Q8 (8-bit)    FP16
  7B params      ~4.3 GB       ~7.5 GB       ~14 GB
  13B params     ~7.9 GB       ~13.9 GB      ~26 GB
  70B params     ~42.7 GB      ~74.9 GB      ~140 GB

Most people use 4-bit quantization (Q4_K_M) which gives 90-95% of full quality at a fraction of the memory. A 24 GB GPU can comfortably run most 7B-13B models.
Estimated: 140.0 tok/s decode · 1.4s TTFT (warm) · 350 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	C	Runs well	140.0 tok/s	754 ms	3.4M
Coding	C	Runs well	140.0 tok/s	1383 ms	3.4M
Agentic Coding	C	Runs well	140.0 tok/s	2011 ms	3.4M
Reasoning	C	Runs well	140.0 tok/s	1634 ms	3.4M
RAG	C	Runs well	140.0 tok/s	2514 ms	3.4M

Quantization options

How HelpingAI2.5 10B i1 (10B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	3.9 GB	Low	D35
Q3_K_S	3	4.9 GB	Low	D35
NVFP4	4

Get started

Copy-paste commands to run HelpingAI2.5 10B i1 on your machine.

Run

lms load hf-mradermacher--helpingai2-5-10b-i1-gguf && lms server start

Frequently asked questions

Can AMD Instinct MI350X 288GB run HelpingAI2.5 10B i1?

Yes, AMD Instinct MI350X 288GB can run HelpingAI2.5 10B i1 with a C grade (Runs well). Expected decode speed: 140.0 tok/s.

How much VRAM does HelpingAI2.5 10B i1 need?

HelpingAI2.5 10B i1 (10B parameters) requires approximately 37.0 GB of memory with Q4_K_M quantization.

What is the best quantization for HelpingAI2.5 10B i1?

The recommended quantization for HelpingAI2.5 10B i1 is Q4_K_M, which balances quality and memory efficiency.

What speed will HelpingAI2.5 10B i1 run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, HelpingAI2.5 10B i1 achieves approximately 140.0 tokens per second decode speed with a time-to-first-token of 1383ms using Q4_K_M quantization.

Can AMD Instinct MI350X 288GB run HelpingAI2.5 10B i1 for coding?

For coding workloads, HelpingAI2.5 10B i1 on AMD Instinct MI350X 288GB receives a C grade with 140.0 tok/s and 3.4M context.

What context window can HelpingAI2.5 10B i1 use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, HelpingAI2.5 10B i1 can safely use up to 3.4M tokens of context. The model's official context limit is —, but available memory constrains the safe maximum.

See all results for AMD Instinct MI350X 288GB See all hardware for HelpingAI2.5 10B i1

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