Can Mistral Small 24B Instruct 2501 run on RX 6800 16GB?

Q: What should I upgrade first if Mistral Small 24B Instruct 2501 feels slow on RX 6800 16GB?

Remove offload with more accelerator memory. Prioritize a GPU or unified-memory tier that fits the whole model natively. Removing offload usually helps more than small compute gains.

YES — With NVFP4

D37Poor

Estimated from fit model

Mistral Small 24B Instruct 2501 needs ~18.8 GB VRAM. RX 6800 16GB has 16.0 GB. With NVFP4 quantization, expect ~12 tok/s.

Runtime: llama.cppCapacity: OffloadBandwidth: MediumStack: StandardBottleneck: Host offload

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Mistral Small 24B Instruct 2501 at Q4_K_M needs 20.0 GB — too much for RX 6800 16GB (16.0 GB). Runs at NVFP4 (18.8 GB) with medium quality. 3 quantization levels fit.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 20.0 GB, exceeds 16.0 GB available

20.0 GB required16.0 GB available

125% VRAM needed

4.0 GB over capacity — needs offload or smaller quantization

Fit status

Too heavy

Decode

9.1 tok/s

TTFT

21359 ms

Safe context

Memory

20.0 GB / 16.0 GB

Offload

20%

Memory breakdown

Weights14.6 GB

KV Cache2.8 GB

Runtime0.9 GB

Headroom1.6 GB

See how fast it feels

With memory offload — actual speed may be lower

See how fast it feelsMistral Small 24B Instruct 2501 on RX 6800 16GB
1st promptCold start — includes initialization
>What is local AI inference?
Local AI inference means running an AI language model directly on your own hardware — your laptop, desktop, or server — instead of sending requests to a remote cloud API.

When you run inference locally the model weights are loaded into your GPU or unified memory. Each token you generate requires reading those weights from memory, so memory bandwidth is the main bottleneck for decode speed.

Key benefits of running locally:
  - Full privacy: your prompts never leave your machine
  - No per-token cost or rate limits
  - Works offline once the model is downloaded
  - Latency depends only on your hardware
2nd promptWarm — model ready, no init overhead
>How much VRAM do I need?
It depends on the model size and quantization level. A rough rule of thumb:

  Model size     Q4 (4-bit)    Q8 (8-bit)    FP16
  7B params      ~4.3 GB       ~7.5 GB       ~14 GB
  13B params     ~7.9 GB       ~13.9 GB      ~26 GB
  70B params     ~42.7 GB      ~74.9 GB      ~140 GB

Most people use 4-bit quantization (Q4_K_M) which gives 90-95% of full quality at a fraction of the memory. A 24 GB GPU can comfortably run most 7B-13B models.
Estimated: 9.1 tok/s decode · 21.4s TTFT (warm) · 23 tok/s prefill

What limits this setup

It fits through host-memory offload, and offload is the main reason performance drops.

CPU or host-memory offload is active

About 10% of the working set spills out of accelerator memory, which usually hurts latency and sustained decode throughput.

Very little memory headroom

You can run the model, but there is not much room left for longer context, bigger batches, extra apps, or future model updates.

Best improvement path

Remove offload with more accelerator memory

Prioritize a GPU or unified-memory tier that fits the whole model natively. Removing offload usually helps more than small compute gains.

Buy headroom, not only minimum fit

A slightly larger memory tier gives you safer context growth and makes the recommendation more future-proof.

Increase host RAM if you keep offloading

This setup may need roughly 2.0 GB of extra host RAM just for the offloaded portion, before OS and other tools.

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	D	Very compromised (needs ~2 GB host RAM)	10.6 tok/s	9989 ms	4K
Coding	F	Too heavy	9.1 tok/s	21359 ms	4K
Agentic Coding	F	Too heavy	6.9 tok/s	41007 ms	4K
Reasoning	F	Too heavy	9.1 tok/s	25242 ms	4K
RAG	F	Too heavy	6.9 tok/s	51258 ms	4K

Quantization options

How Mistral Small 24B Instruct 2501 (24B params) fits at each quantization level on RX 6800 16GB (16.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	9.4 GB	Low	C51
Q3_K_SBest for your GPU	3	11.8 GB	Low	C51

Get started

Copy-paste commands to run Mistral Small 24B Instruct 2501 on your machine.

Run

lms load hf-maziyarpanahi--mistral-small-24b-instruct-2501-gguf && lms server start

Upgrade options

Hardware that runs Mistral Small 24B Instruct 2501 well

RX 7900 XT 20GBBudget pick

20 GB VRAM (+4)800 GB/s (+288)

Makes the model fit on the accelerator instead of staying completely out of reach.23.7 tok/s decode

Makes the model fit on the accelerator instead of staying completely out of reach.

Removes host-memory offload, which is usually the single biggest latency and throughput win.

~$899 MSRP

RX 7900 XTX 24GBBest value

24 GB VRAM (+8)960 GB/s (+448)

Makes the model fit on the accelerator instead of staying completely out of reach.47.2 tok/s decode

Makes the model fit on the accelerator instead of staying completely out of reach.

Removes host-memory offload, which is usually the single biggest latency and throughput win.

~$999 MSRP

Radeon AI PRO R9700 32GBAMD upgrade

32 GB VRAM (+16)640 GB/s (+128)

Makes the model fit on the accelerator instead of staying completely out of reach.25.8 tok/s decode

Makes the model fit on the accelerator instead of staying completely out of reach.

Removes host-memory offload, which is usually the single biggest latency and throughput win.

~$1,899 MSRP

Frequently asked questions

Can RX 6800 16GB run Mistral Small 24B Instruct 2501?

Yes, RX 6800 16GB can run Mistral Small 24B Instruct 2501 at NVFP4 quantization (Very compromised (needs ~2 GB host RAM)). The recommended Q4_K_M requires 20.0 GB which exceeds available memory, but at NVFP4 it needs only 18.8 GB. Expected decode speed: 11.8 tok/s.

How much VRAM does Mistral Small 24B Instruct 2501 need?

Mistral Small 24B Instruct 2501 (24B parameters) requires approximately 20.0 GB at Q4_K_M quantization. On RX 6800 16GB, it fits at NVFP4 using 18.8 GB.

What is the best quantization for Mistral Small 24B Instruct 2501?

The recommended quantization is Q4_K_M, but on RX 6800 16GB the best fitting quantization is NVFP4, which uses 18.8 GB.

What speed will Mistral Small 24B Instruct 2501 run at on RX 6800 16GB?

On RX 6800 16GB, Mistral Small 24B Instruct 2501 achieves approximately 11.8 tokens per second decode speed with a time-to-first-token of 16388ms using NVFP4 quantization.

Can RX 6800 16GB run Mistral Small 24B Instruct 2501 for coding?

For coding workloads, Mistral Small 24B Instruct 2501 on RX 6800 16GB receives a F grade with 9.1 tok/s and 4K context.

What context window can Mistral Small 24B Instruct 2501 use on RX 6800 16GB?

On RX 6800 16GB, Mistral Small 24B Instruct 2501 can safely use up to 4K tokens of context at NVFP4 quantization. The model's official context limit is —, but available memory constrains the safe maximum.

See all results for RX 6800 16GB See all hardware for Mistral Small 24B Instruct 2501

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