Can Llama 3.3 70B Instruct run on AMD Instinct MI350X 288GB?

YES — Runs Great

C48Usable

Estimated from fit model

Llama 3.3 70B Instruct needs ~80.6 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~137 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 80.6 GB, 136.8 tok/s, Runs well

80.6 GB required288.0 GB available

28% VRAM used

Fit status

Runs well

Decode

136.8 tok/s

TTFT

1416 ms

Safe context

421K

Memory

80.6 GB / 288.0 GB

Memory breakdown

Weights42.7 GB

KV Cache8.2 GB

Runtime0.9 GB

Headroom28.8 GB

See how fast it feels

See how fast it feelsLlama 3.3 70B Instruct on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>What is local AI inference?
Local AI inference means running an AI language model directly on your own hardware — your laptop, desktop, or server — instead of sending requests to a remote cloud API.

When you run inference locally the model weights are loaded into your GPU or unified memory. Each token you generate requires reading those weights from memory, so memory bandwidth is the main bottleneck for decode speed.

Key benefits of running locally:
  - Full privacy: your prompts never leave your machine
  - No per-token cost or rate limits
  - Works offline once the model is downloaded
  - Latency depends only on your hardware
2nd promptWarm — model ready, no init overhead
>How much VRAM do I need?
It depends on the model size and quantization level. A rough rule of thumb:

  Model size     Q4 (4-bit)    Q8 (8-bit)    FP16
  7B params      ~4.3 GB       ~7.5 GB       ~14 GB
  13B params     ~7.9 GB       ~13.9 GB      ~26 GB
  70B params     ~42.7 GB      ~74.9 GB      ~140 GB

Most people use 4-bit quantization (Q4_K_M) which gives 90-95% of full quality at a fraction of the memory. A 24 GB GPU can comfortably run most 7B-13B models.
Estimated: 136.8 tok/s decode · 1.4s TTFT (warm) · 342 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	C	Runs well	136.8 tok/s	772 ms	421K
Coding	C	Runs well	136.8 tok/s	1416 ms	421K
Agentic Coding	C	Runs well	136.8 tok/s	2059 ms	421K
Reasoning	C	Runs well	136.8 tok/s	1673 ms	421K
RAG	C	Runs well	136.8 tok/s	2574 ms	421K

Quantization options

How Llama 3.3 70B Instruct (70B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	27.3 GB	Low	D37
Q3_K_S	3	34.3 GB	Low	D38
NVFP4	4	39.2 GB	Medium	D38
Q4_K_M	4	42.7 GB	Medium	D39
Q5_K_M	5	50.4 GB	High	D39
Q6_K	6	57.4 GB	High	D40
Q8_0	8	74.9 GB	Very High	C41
F16Best for your GPU	16	143.5 GB	Maximum	C46

Get started

Copy-paste commands to run Llama 3.3 70B Instruct on your machine.

Run

lms load hf-maziyarpanahi--llama-3-3-70b-instruct-gguf && lms server start

Frequently asked questions

Can AMD Instinct MI350X 288GB run Llama 3.3 70B Instruct?

Yes, AMD Instinct MI350X 288GB can run Llama 3.3 70B Instruct with a C grade (Runs well). Expected decode speed: 136.8 tok/s.

How much VRAM does Llama 3.3 70B Instruct need?

Llama 3.3 70B Instruct (70B parameters) requires approximately 80.6 GB of memory with Q4_K_M quantization.

What is the best quantization for Llama 3.3 70B Instruct?

The recommended quantization for Llama 3.3 70B Instruct is Q4_K_M, which balances quality and memory efficiency.

What speed will Llama 3.3 70B Instruct run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Llama 3.3 70B Instruct achieves approximately 136.8 tokens per second decode speed with a time-to-first-token of 1416ms using Q4_K_M quantization.

Can AMD Instinct MI350X 288GB run Llama 3.3 70B Instruct for coding?

For coding workloads, Llama 3.3 70B Instruct on AMD Instinct MI350X 288GB receives a C grade with 136.8 tok/s and 421K context.

What context window can Llama 3.3 70B Instruct use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Llama 3.3 70B Instruct can safely use up to 421K tokens of context. The model's official context limit is —, but available memory constrains the safe maximum.

See all results for AMD Instinct MI350X 288GB See all hardware for Llama 3.3 70B Instruct

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<iframe src="https://willitrunai.com/embed/hf-maziyarpanahi--llama-3-3-70b-instruct-gguf-on-instinct-mi350x-288gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>

Preview:

Workload

Grade

Fit

Decode

TTFT

Context

Chat

Runs well

136.8 tok/s

772 ms

421K

Coding

Runs well

136.8 tok/s

1416 ms

421K

Agentic Coding

Runs well

136.8 tok/s

2059 ms

421K

Reasoning

Runs well

136.8 tok/s

1673 ms

421K

RAG

Runs well

136.8 tok/s

2574 ms

421K

Quantization options

How Llama 3.3 70B Instruct (70B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	27.3 GB	Low	D37
Q3_K_S	3	34.3 GB	Low	D38
NVFP4	4	39.2 GB	Medium	D38
Q4_K_M	4	42.7 GB	Medium	D39
Q5_K_M	5	50.4 GB	High	D39
Q6_K	6	57.4 GB	High	D40
Q8_0	8	74.9 GB	Very High	C41
F16Best for your GPU	16	143.5 GB	Maximum	C46

Frequently asked questions

Can AMD Instinct MI350X 288GB run Llama 3.3 70B Instruct?

Yes, AMD Instinct MI350X 288GB can run Llama 3.3 70B Instruct with a C grade (Runs well). Expected decode speed: 136.8 tok/s.

How much VRAM does Llama 3.3 70B Instruct need?

Llama 3.3 70B Instruct (70B parameters) requires approximately 80.6 GB of memory with Q4_K_M quantization.

What is the best quantization for Llama 3.3 70B Instruct?

The recommended quantization for Llama 3.3 70B Instruct is Q4_K_M, which balances quality and memory efficiency.

What speed will Llama 3.3 70B Instruct run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Llama 3.3 70B Instruct achieves approximately 136.8 tokens per second decode speed with a time-to-first-token of 1416ms using Q4_K_M quantization.

Can AMD Instinct MI350X 288GB run Llama 3.3 70B Instruct for coding?

For coding workloads, Llama 3.3 70B Instruct on AMD Instinct MI350X 288GB receives a C grade with 136.8 tok/s and 421K context.

What context window can Llama 3.3 70B Instruct use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Llama 3.3 70B Instruct can safely use up to 421K tokens of context. The model's official context limit is —, but available memory constrains the safe maximum.