DiffusionGemma 26B A4B needs ~28.2 GB VRAM. AMD Instinct MI210 64GB has 64.0 GB. With Q4_K_M quantization, expect ~133 tok/s.
Operating mode
Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.
Current mode
Balanced
Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.
Select quantization to explore
Fit status
Runs well
Decode
133.2 tok/s
TTFT
1454 ms
Safe context
172K
Memory
28.2 GB / 64.0 GB
This setup is broadly balanced for this model.
No major red flags
This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.
| Workload | Grade | Fit | Decode | TTFT | Context |
|---|---|---|---|---|---|
| Chat | A | Runs well | 133.2 tok/s | 793 ms | 172K |
| Coding | A | Runs well | 133.2 tok/s | 1454 ms | 172K |
| Agentic Coding | A | Runs well | 133.2 tok/s | 2114 ms | 172K |
| Reasoning | A | Runs well | 133.2 tok/s | 1718 ms | 172K |
| RAG | A | Runs well | 133.2 tok/s | 2643 ms | 172K |
Inference speed
Estimated decode speed (tokens/sec) for DiffusionGemma 26B A4B at Q4_K_M across popular GPUs and Apple Silicon, using the fastest local runtime per device. Fastest is RTX 5090 32GB at ~144 tok/s. Speed is memory-bandwidth bound, so cards that fit the whole model in VRAM run far faster than ones that offload to system RAM.
| GPU / Mac | Memory | Quant | Speed (tok/s) | Fits? |
|---|---|---|---|---|
 RTX 5090 32GB | 32 GB | Q4_K_M | 143.6 | Fits |
| RTX 4090 24GB | 24 GB | Q4_K_M | 67.5 | Too big |
Mac Studio M3 Ultra 256GB | 256 GB | Q4_K_M | 66.6 | Fits |
RX 7900 XTX 24GB | 24 GB | Q4_K_M | 60.9 | Too big |
| RTX 3090 24GB | 24 GB | Q4_K_M | 57.7 | Too big |
Mac Studio M2 Ultra 128GB | 128 GB | Q4_K_M | 55.5 | Fits |
Mac Studio M1 Ultra 128GB | 128 GB | Q4_K_M | 52.6 | Fits |
MacBook Pro M4 Max 128GB | 128 GB | Q4_K_M | 41.1 | Fits |
MacBook Pro M4 Max 64GB | 64 GB | Q4_K_M | 41.1 | Fits |
MacBook Pro M3 Max 64GB | 64 GB | Q4_K_M | 28.7 | Fits |
MacBook Pro M1 Max 64GB | 64 GB | Q4_K_M | 26.3 | Fits |
MacBook Pro M4 Pro 48GB | 48 GB | Q4_K_M | 25.1 | Fits |
| RTX 4080 Super 16GB | 16 GB | Q4_K_M | 24.6 | Too big |
| RTX 4070 12GB | 12 GB | Q4_K_M | 8.6 | Too big |
| RTX 3060 12GB | 12 GB | Q4_K_M | 5.4 | Too big |
| RTX 4060 8GB | 8 GB | Q4_K_M | 3.6 | Too big |
Estimates for single-stream decoding at Q4_K_M; real tokens/sec varies with prompt length, context, batch size, and runtime build. Prompt processing (prefill) is faster than the decode figures shown here.
How DiffusionGemma 26B A4B (25.799999237060547B params) fits at each quantization level on AMD Instinct MI210 64GB (64.0 GB usable).
| Quant | Bits | VRAM | Quality | Fit |
|---|---|---|---|---|
Q2_K | 2 | 10.1 GB | Low | A70 |
Q3_K_S | 3 | 12.6 GB | Low | A71 |
NVFP4 | 4 | 14.4 GB | Medium | A71 |
Q4_K_M | 4 | 15.7 GB | Medium | A71 |
Q5_K_M | 5 | 18.6 GB | High | A72 |
Q6_K | 6 | 21.2 GB | High | A72 |
Q8_0 | 8 | 27.6 GB | Very High | A74 |
F16Best for your GPU | 16 | 52.9 GB | Maximum | A77 |
Copy-paste commands to run DiffusionGemma 26B A4B on your machine.
Run
docker run --rm -it ghcr.io/ggerganov/llama.cpp:full \
--hf-repo "google/diffusiongemma-26B-A4B-it" \
--hf-file "diffusiongemma-26B-A4B-it-Q4_K_M.gguf" \
-c 4096 -ngl 99Your hardware
| Model | Params | Grade | Decode | Capabilities |
|---|---|---|---|---|
 Qwen3-Coder 30B A3B Instruct | 30.5B | S | 128 tok/s | |
| Qwen 3.5 27B | 27B | S | 58.4 tok/s | |
| Qwen 3.6 27B | 27B | S | 58.6 tok/s | |
| Qwen 3.6 35B A3B | 35B | S | 107.6 tok/s | |
| Qwen3-VL 30B A3B Instruct | 30B | S | 132.4 tok/s |
Yes, AMD Instinct MI210 64GB can run DiffusionGemma 26B A4B with a A grade (Runs well). Expected decode speed: 133.2 tok/s.
DiffusionGemma 26B A4B (25.799999237060547B parameters) requires approximately 28.2 GB of memory with Q4_K_M quantization.
The recommended quantization for DiffusionGemma 26B A4B is Q4_K_M, which balances quality and memory efficiency.
On AMD Instinct MI210 64GB, DiffusionGemma 26B A4B achieves approximately 133.2 tokens per second decode speed with a time-to-first-token of 1454ms using Q4_K_M quantization.
For coding workloads, DiffusionGemma 26B A4B on AMD Instinct MI210 64GB receives a A grade with 133.2 tok/s and 172K context.
On AMD Instinct MI210 64GB, DiffusionGemma 26B A4B can safely use up to 172K tokens of context. The model's official context limit is 262K, but available memory constrains the safe maximum.
Paste this snippet into any page to show a live fit card.
<iframe src="https://willitrunai.com/embed/diffusiongemma-26b-a4b-on-instinct-mi210-64gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>
Preview: