Can Codestral 22B run on AMD Instinct MI250 128GB?

YES — Runs Great

B57Good

Estimated from fit model

Codestral 22B needs ~29.6 GB VRAM. AMD Instinct MI250 128GB has 128.0 GB. With Q4_K_M quantization, expect ~174 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 29.6 GB, 174.3 tok/s, Runs well

29.6 GB required128.0 GB available

23% VRAM used

Fit status

Runs well

Decode

174.3 tok/s

TTFT

1111 ms

Safe context

33K

Memory

29.6 GB / 128.0 GB

Memory breakdown

Weights13.4 GB

KV Cache2.4 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsCodestral 22B on AMD Instinct MI250 128GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers))  # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
    """Sort a list using the quicksort algorithm.

    Args:
        arr: List of integers to sort.

    Returns:
        A new sorted list.
    """
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 174.3 tok/s decode · 1.1s TTFT (warm) · 436 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	B	Runs well	174.3 tok/s	606 ms	33K
Coding	B	Runs well	174.3 tok/s	1111 ms	33K
Agentic Coding	B	Runs well	174.3 tok/s	1616 ms	33K
Reasoning	B	Runs well	174.3 tok/s	1313 ms	33K
RAG	B	Runs well	174.3 tok/s	2019 ms	33K

Quantization options

How Codestral 22B (22B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	8.6 GB	Low	C48
Q3_K_S	3	10.8 GB	Low	C48
NVFP4	4	12.3 GB	Medium	C49
Q4_K_M	4	13.4 GB	Medium	C49
Q5_K_M	5	15.8 GB	High	C49
Q6_K	6	18.0 GB	High	C49
Q8_0	8	23.5 GB	Very High	C49
F16Best for your GPU	16	45.1 GB	Maximum	C53

Get started

Copy-paste commands to run Codestral 22B on your machine.

Run

ollama run codestral

Frequently asked questions

Can AMD Instinct MI250 128GB run Codestral 22B?

Yes, AMD Instinct MI250 128GB can run Codestral 22B with a B grade (Runs well). Expected decode speed: 174.3 tok/s.

How much VRAM does Codestral 22B need?

Codestral 22B (22B parameters) requires approximately 29.6 GB of memory with Q4_K_M quantization.

What is the best quantization for Codestral 22B?

The recommended quantization for Codestral 22B is Q4_K_M, which balances quality and memory efficiency.

What speed will Codestral 22B run at on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Codestral 22B achieves approximately 174.3 tokens per second decode speed with a time-to-first-token of 1111ms using Q4_K_M quantization.

Can AMD Instinct MI250 128GB run Codestral 22B for coding?

For coding workloads, Codestral 22B on AMD Instinct MI250 128GB receives a B grade with 174.3 tok/s and 33K context.

What context window can Codestral 22B use on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Codestral 22B can safely use up to 33K tokens of context. The model's official context limit is 33K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250 128GB See all hardware for Codestral 22B

Embed this result▼

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<iframe src="https://willitrunai.com/embed/codestral-22b-on-instinct-mi250-128gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>

Preview:

Workload

Grade

Fit

Decode

TTFT

Context

Chat

Runs well

174.3 tok/s

606 ms

33K

Coding

Runs well

174.3 tok/s

1111 ms

33K

Agentic Coding

Runs well

174.3 tok/s

1616 ms

33K

Reasoning

Runs well

174.3 tok/s

1313 ms

33K

RAG

Runs well

174.3 tok/s

2019 ms

33K

Quantization options

How Codestral 22B (22B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	8.6 GB	Low	C48
Q3_K_S	3	10.8 GB	Low	C48
NVFP4	4	12.3 GB	Medium	C49
Q4_K_M	4	13.4 GB	Medium	C49
Q5_K_M	5	15.8 GB	High	C49
Q6_K	6	18.0 GB	High	C49
Q8_0	8	23.5 GB	Very High	C49
F16Best for your GPU	16	45.1 GB	Maximum	C53

Frequently asked questions

Can AMD Instinct MI250 128GB run Codestral 22B?

Yes, AMD Instinct MI250 128GB can run Codestral 22B with a B grade (Runs well). Expected decode speed: 174.3 tok/s.

How much VRAM does Codestral 22B need?

Codestral 22B (22B parameters) requires approximately 29.6 GB of memory with Q4_K_M quantization.

What is the best quantization for Codestral 22B?

The recommended quantization for Codestral 22B is Q4_K_M, which balances quality and memory efficiency.

What speed will Codestral 22B run at on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Codestral 22B achieves approximately 174.3 tokens per second decode speed with a time-to-first-token of 1111ms using Q4_K_M quantization.

Can AMD Instinct MI250 128GB run Codestral 22B for coding?

For coding workloads, Codestral 22B on AMD Instinct MI250 128GB receives a B grade with 174.3 tok/s and 33K context.

What context window can Codestral 22B use on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Codestral 22B can safely use up to 33K tokens of context. The model's official context limit is 33K, but available memory constrains the safe maximum.